Certain physiological changes associated with aging may affect the
disposition and action of drugs within the body (see table below).
|
Physiological Changes
Associated with Aging that Affect Drug Dynamics |
|
Parameter |
Physiological Change
with Aging |
|
stomach emptying
|
|
stomach acidity
|
|
gastrointestinal passage
|
|
to spleen blood flow
|
|
absorption through intestinal wall
|
|
cardiac output
|
|
muscle mass
|
|
body fat
|
|
activity of certain liver enzymes
|
|
liver blood flow
|
|
kidney blood flow and filtration rate
|